Ventilator associated pneumonia: mechanisms, an appraisal of current therapies and the role for inhaled antibiotics in prevention and treatment Respiratory Medicine VAP Bundle Ventilator Associated Pneumonia Ventilator Associated Pneumonia ( VAP) is a lung infection that occurs in patients who are on mechanical ventilation for more than 48 hours. A VAP bundle is a set of VENTILATOR = LIFE SUPPORT but also VAP RISK. Up to 20% of ventilated patients >48 hrs develop VAP. Mortality? Can reach 50%. Here's what actually matters in ICU rounds Figure 1 from Ventilator associated pneumonia: a review. Semantic Scholar